Stefan de Vrij returns and Alexis Sanchez gets a chance upfront with Lautaro Martinez, as Inter know a win over Cagliari would make them the new leaders.
It kicks off at San Siro at 19.45 GMT, you can follow all the build-up and action as it happens on the LIVEBLOG.
Milan were held to a 1-1 draw by Udinese last night, so a victory here would allow the Nerazzurri to leapfrog to the top spot.
De Vrij returns in defence after a lay-off, with Andrea Ranocchia, Mattia Darmian and Joaquin Correa out of action.
Edin Dzeko is rested in favour of Alexis Sanchez with Lautaro Martinez upfront.
Cagliari are still without a win under coach Walter Mazzarri, but have played four consecutive stalemates, so are making themselves tough to beat too.
There are problems, as Kevin Strootman had knee surgery this week, while Nahitan Nandez, Sebastian Walukiewicz and Marko Rog are also out of action.
Keita Balde Diao, Diego Godin and Henrique Dalbert face their former club at San Siro, but Joao Pedro is the form striker for the Sardinians.
Inter: Handanovic; Skriniar, De Vrij, Bastoni; Dumfries, Barella, Brozovic, Calhanoglu, Perisic; Alexis Sanchez, Lautaro Martinez
Cagliari: Cragno; Caceres, Godin, Carboni; Bellanova, Deiola, Marin, Grassi, Dalbert; Keita, Joao Pedro