Inter have Marcelo Brozovic and Alessandro Bastoni back with Alexis Sanchez after a shock defeat, as they visit a Genoa side who drew all four games under coach Alexander Blessin.
It kicks off at the Stadio Luigi Ferraris, known as Marassi, at 20.00 GMT.
The Nerazzurri have been shaken in recent weeks by poor results, picking up one point from the last three Serie A rounds and falling 2-0 at home to Liverpool in the Champions League.
Brozovic and Bastoni both return from suspension, having been sorely missed in the 2-0 home defeat to Sassuolo.
Joaquin Correa and Robin Gosens are still out of action, but Matias Vecino returns to the bench, while Edin Dzeko and Alexis Sanchez lead the way upfront.
Genoa have drawn all four games under coach Alexander Blessin, their third boss of the campaign after Davide Ballardini and Andriy Shevchenko.
This historic club sits in penultimate place with just one Serie A victory all season, 3-2 away to Cagliari back on September 12.
Domenico Criscito, Roberto Piccoli, Mattia Bani and Inter-owned Zinho Vanheusden are out injured.
Mattia Destro is surprisingly dropped and the system changed with a trio supporting January signing Kelvin Yeboah.
Genoa: Sirigu; Hefti, Maksimovic, Ostigard, Vasquez; Sturaro, Badelj; Gudmundsson, Melegoni, Portanova; Yeboah
Inter: Handanovic; D’Ambrosio, De Vrij, Bastoni; Dumfries, Barella, Brozovic, Calhanoglu, Perisic; Dzeko, Alexis Sanchez