Cagliari are desperate to get off the foot of the table and look to Joao Pedro, while Atalanta start Ruslan Malinovskyi and Duvan Zapata.
It kicks off at the Sardegna Arena at 19.45 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
Serie A Liveblog: Spezia-Torino, Juventus-Fiorentina, Cagliari-Atalanta
The Sardinians have not improved since Walter Mazzarri took over from sacked Leonardo Semplici, so they went into a training retreat this week to help prepare for the match.
Keita Balde Diao didn’t take part, as he was in hospital to remove an abscess on his tonsils.
He joins injured Dalbert, Marko Rog, Paolo Faragò, Damir Ceter and suspended Martin Caceres in the stands.
Nahitan Nandez is carrying a knock, but starts anyway with Joao Pedro as the sole centre-forward.
Atalanta are still wondering how they managed to again fumble a lead with Manchester United, drawing 2-2 midweek in the Champions League.
It was the same scoreline they had against Lazio, winning just one of their last five competitive matches.
Jose Luis Palomino returns from suspension, though Rafael Toloi, Robin Gosens and Hans Hateboer are still on the treatment table.
Duvan Zapata is picked to partner Malinovskyi upfront, with Mario Pasalic in the trequartista role.
Matteo Pessina is in the squad for the first time since his thigh strain.
Cagliari: Cragno; Bellanova, Zappa, Godin, Carboni; Nandez, Marin, Strootman, Deiola, Lykogiannis; Joao Pedro
Atalanta: Musso; De Roon, Demiral, Palomino; Zappacosta, Koopmeiners, Freuler, Maehle; Pasalic; Malinovskyi, Duvan Zapata