Juventus look to Federico Chiesa and Dusan Vlahovic with new signings Timothy Weah and Andrea Cambiaso for the trip to Beto’s Udinese.
It kicks off at the Dacia Arena at 19.45 UK time (18.45 GMT).
The Bianconeri have had a tense summer with their exclusion from UEFA competitions, but can finally put the 10-point penalty behind them and start from scratch.
Moise Kean joined Mattia De Sciglio on the treatment table, while Leonardo Bonucci is frozen out pending a transfer.
Chiesa is used as a striker in support of Vlahovic, with new buys Weah and Cambiaso on the wings, plus Paul Pogba ready to come off the bench.
Udinese have quite a few injury problems, missing Gerard Deulofeu, Simone Pafundi, Enzo Ebosse, Kingsley Ehizibue, Adam Masina and Daniele Padelli.
Lazar Samardzic is in the squad, but only on the bench after his move to Inter sensationally collapsed.
Beto and Florian Thauvin get support from newcomers Oier Zarraga and Kamara.
Udinese: Silvestri; Perez, Bijol, Kabasele; Ebosele, Zarraga, Walace, Lovric, Kamara; Thauvin, Beto
Juventus: Szczesny; Danilo, Bremer, Alex Sandro; Weah, Rabiot, Locatelli, Miretti, Cambiaso; Chiesa, Vlahovic