Juventus start Moise Kean with Dusan Vlahovic and drop Leonardo Bonucci in the Derby della Mole, while arch-rivals Torino have to reshuffle in attack with Nikola Vlasic.
It kicks off at the Stadio Olimpico Grande Torino at 17.00 UK time (16.00 GMT).
This has always been a derby that mattered more to the Granata side of the city, but this time it becomes crucial for the Bianconeri too, because they have had a disastrous start to the campaign.
The squad went into a training retreat after the 2-0 Champions League loss to Maccabi Haifa, while a defeat here would see the Old Lady leapfrogged in the Serie A standings by their less prestigious neighbours.
Max Allegri is without injured Angel Di Maria, Mattia De Sciglio, Federico Chiesa, Paul Pogba and Kaio Jorge.
Arkadiusz Milik is also not 100 per cent fit, so sits on the bench, as Moise Kean is chosen to partner Dusan Vlahovic.
There is a big surprise in defence, where Leonardo Bonucci is dropped in favour of Bremer and Danilo, especially considering there is no midweek game coming up, so rest shouldn’t be an issue.
Torino have injury problems too, missing Antonio Sanabria, with Pietro Pellegri and Samuele Ricci at best fit for a spot on the bench.
It means coach Ivan Juric has no real strikers to call on, so Nikola Vlasic is pushed up with support from Aleksei Miranchuk and Nemanja Radonjic.
Toro picked up just one point in their last four games and have not won the Derby della Mole since a 2-1 result in April 2015.
They’ve managed only four draws in the last 16 meetings with Juventus, between Serie A and the Coppa Italia.
It is a special day for Torino too, the 55th anniversary of the tragic death of their legendary striker Gigi Meroni, who was hit by a car crossing the street in Turin in 1967.
Torino: Milinkovic-Savic; Djidji, Schuurs, Rodriguez; Aina, Lukic, Linetty, Lazaro; Miranchuk, Vlasic, Radonjic
Juventus: Szczesny; Cuadrado, Bremer, Danilo, Alex Sandro; McKennie, Locatelli, Rabiot, Kostic; Vlahovic, Kean