It’s going to be a fascinating clash between high-scoring and high-flying teams, as Ciro Immobile and Sergej Milinkovic-Savic’s Lazio host Gerard Deulofeu and Udinese in a fight for third place.
It kicks off at the Stadio Olimpico at 14.00 UK time (13.00 GMT).
This is a real battle for third place, as both teams are on 20 points along with Milan going into this weekend.
Lazio have won their last four Serie A games in a row, scoring a total 14 goals and conceding zero, while Udinese saw their run of six consecutive victories stalled by a 2-2 draw against Atalanta.
Maurizio Sarri’s men played on Thursday in the Europa League, drawing 2-2 with Sturm Graz after Manuel Lazzari’s harsh red card.
Milinkovic-Savic supports Immobile, flanked by Felipe Anderson and Mattia Zaccagni, with Matias Vecino preferred to Luis Alberto.
Udinese are again inspired by Roberto Pereyra and Gerard Deulofeu, with Beto getting the nod instead of Isaac Success.
Lazio: Provedel; Lazzari, Casale, Romagnoli, Marusic; Milinkovic-Savic, Cataldi, Vecino; Felipe Anderson, Immobile, Zaccagni
Udinese: Silvestri; Becao, Bijol, Perez; Pereyra, Samardzic, Walace, Makengo, Udogie; Deulofeu, Beto