Juventus are decimated for the Derby d’Italia, as Dusan Vlahovic is ruled out too, while Inter look to Lautaro Martinez and Nicolò Barella.
It kicks off at the Allianz Juventus Stadium at 19.45 GMT.
The season has not started on the right foot for either of these giants, who saw their Scudetto ambitions evaporate almost immediately.
They’re starting to get it back on track, although Juve crashed out of the Champions League after five defeats in six games.
Vlahovic failed a fitness test this morning on a groin inflammation, joining Leandro Paredes, Moise Kean, Weston McKennie, Samuel Iling-Junior, Mattia De Sciglio, Kaio Jorge and Paul Pogba on the treatment table.
The good news for Max Allegri is that Angel Di Maria, Gleison Bremer and Federico Chiesa are available again, but only the defender starts.
Arkadiusz Milik therefore leads the attack for the Old Lady, but Leonardo Bonucci is benched.
Inter are missing Romelu Lukaku, Marcelo Brozovic and Danilo D’Ambrosio, while defender Alessandro Bastoni was in doubt after suffering from flu symptoms over the last couple of days.
Juventus: Szczesny; Danilo, Bremer, Alex Sandro; Cuadrado, Fagioli, Locatelli, Rabiot, Kostic; Miretti; Milik
Inter: Onana; Skriniar, De Vrij, Acerbi; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Dzeko, Lautaro Martinez