Olivier Giroud and Theo Hernandez are suspended, so Milan start Divock Origi and Malick Thiaw with Ante Rebic and Brahim Diaz for the trip to Cremonese.
It kicks off at the Stadio Giovanni Zini at 19.45 GMT.
The Rossoneri continue the defence of their Serie A title without Giroud and Theo Hernandez, who are suspended after the last-gasp win over Spezia.
Mike Maignan, Davide Calabria, Sergino Dest, Alexis Saelemaekers, Alessandro Florenzi and Zlatan Ibrahimovic are also still out of action.
Origi is therefore the only available centre-forward, with support from Ante Rebic and Brahim Diaz, as Rafael Leao is rested.
The big surprise is that Malick Thiaw gets his first start in the Rossoneri jersey.
Cremonese are still without a win since their promotion to Serie A, but have been putting in good performances regardless.
Cyriel Dessers, Ionut Radu, Vlad Chiriches and Pablo Ascacibar are all on the treatment table, but ex-Roma talent Felix Afena-Gyan gets the nod with Daniel Ciofani.
Cremonese: Carnesecchi; Aiwu, Bianchetti, Vasquez; Ghiglione, Escalante, Castagnetti, Valeri, Meité; Afena-Gyan, Ciofani
Milan: Tatarusanu; Thiaw, Kjaer, Tomori, Ballo-Touré; Tonali, Bennacer; Messias, Brahim Diaz, Rebic; Origi