Roma have the chance to catch Milan in fifth place, but also vastly rotate ahead of the Europa League semi-final, so Ola Solbakken and Mile Svilar start against Bologna.
It kicks off at the Stadio Dall’Ara at 17.00 UK time (16.00 GMT).
The Giallorossi have a squad stretched incredibly thin by the Europa League semi-final, having beaten Bayer Leverkusen 1-0 on Thursday and preparing for the decider next week.
Paulo Dybala and Rui Patricio are rested, with Chris Smalling, Marash Kumbulla, Diego Llorente, Rick Karsdorp and Stephan El Shaarawy injured.
It means there is a Serie A debut for Mile Svilar in goal, who only made one appearance for the club in the Europa League.
Bologna defender Jhon Lucumi is back in Colombia for the birth of his child, while Roberto Soriano, Nicola Sansone, Adama Soumaoro and Giorgos Kyriakopoulos are injured, plus Stefan Posch suspended.
Marko Arnautovic returns to the starting XI after several months.
Bologna: Skorupski; De Silvestri, Bonifazi, Sosa, Cambiaso; Ferguson, Dominguez, Schouten; Orsolini, Arnautovic, Barrow
Roma: Svilar; Celik, Cristante, Ibanez; Missori, Camara, Tahirovic, Zalewski; Wijnaldum, Solbakken; Belotti
Match statistic
