It’s a top of the table showdown, as Napoli look to Victor Osimhen and Chucky Lozano, while Atalanta trust Ademola Lookman and Rasmus Hojlund.
It kicks off at the Gewiss Stadium in Bergamo at 17.00 GMT.
The Partenopei are the runaway Serie A leaders, but saw their run of 13 consecutive victories ended by Liverpool midweek, even though they still topped the Champions League group.
They are still seeking a ninth League win in a row and visit second-placed Atalanta, who suffered only one defeat all season, at home to Lazio.
Both sides have injury problems, as Kvicha Kvaratskhelia and Amir Rrahmani didn’t make the trip, while Luis Muriel and Davide Zappacosta are on the treatment table.
With Duvan Zapata and Marten de Roon not at 100 per cent either, Gian Piero Gasperini hands the attack to Lookman and Hojlund, who has been nicknamed the new Erling Haaland.
Eljif Elmas steps in with Chucky Lozano and Osimhen for the Napoli trident.
Something has to give, because these sides haven’t shared the points here in Serie A since October 2014, followed by three home wins and four away victories.
Atalanta: Musso; Toloi, Demiral, Scalvini; Hateboer, Pasalic, Koopmeiners, Maehle; Ederson; Lookman, Hojlund
Napoli: Meret; Di Lorenzo, Kim Min-jae, Juan Jesus, Olivera; Anguissa, Lobotka, Zielinski; Lozano, Osimhen, Elmas