Roma are expected to use a three-man defence with Cengiz Under and Radja Nainggolan supporting Edin Dzeko in the Champions League semi-final with Liverpool.
The first leg kicks off at Anfield at 19.45 UK time (18.45 GMT).
Although the Giallorossi lost the first leg of their quarter-final 4-1 away to Barcelona, they dominated the second and won 3-0 to qualify on away goals.
In that match, Coach Eusebio Di Francesco debuted a new three-man system at the back and it proved a masterstroke.
Roma are expected to use a three-man defence with Cengiz Under and Radja Nainggolan supporting Edin Dzeko in the Champions League semi-final with Liverpool.
The first leg kicks off at Anfield at 19.45 UK time (18.45 GMT).
Although the Giallorossi lost the first leg of their quarter-final 4-1 away to Barcelona, they dominated the second and won 3-0 to qualify on away goals.
In that match, Coach Eusebio Di Francesco debuted a new three-man system at the back and it proved a masterstroke.
According to the latest reports, he is inclined to use that tactic again, with Kostas Manolas, Federico Fazio and Juan Jesus.
In attack, Nainggolan is moved to a more advanced role as support for centre-forward Dzeko, with Cengiz Under getting the nod ahead of Patrik Schick.
Liverpool are without injured Emre Can, Adam Lallana and Joel Matip, but captain Jordan Henderson returns after suspension.
Although they spent £75m to make him the most expensive defender in the world, Virgil van Dijk and his teammates in the four-man back line are considered a major weakness by the Italian team.
The danger man is without doubt Mohamed Salah, who left Roma to join the Reds over the summer, and has scored 41 competitive goals this season.
Probable line-ups
Liverpool (4-3-3): Karius, Alexander-Arnold, Lovren, Van Dijk, Robertson; Milner, Henderson, Oxlade-Chamberlain, Salah, Firmino, Mané
Liverpool bench: Mignolet, Clyne, Klavan, Moreno, Solanke, Wijnaldum, Ings
Roma (3-4-2-1): Alisson; Manolas, Fazio, Juan Jesus; Florenzi, De Rossi, Strootman, Kolarov; Nainggolan, Under; Dzeko
Roma: Skorupski, Bruno Peres, Pellegrini, Gonalons, 1Schick,El Shaarawy, Perotti
Ref: Brych (GER)