Napoli are expected to drop Dries Mertens and Marek Hamsik in favour of Aradkiusz Milik and Fabian Ruiz against Liverpool.
It kicks off at the Stadio San Paolo at 20.00 UK time (19.00 GMT).
The Partenopei are fresh from a narrow defeat to Juventus in the top of the Serie A table showdown, which saw Mario Rui sent off for two bookable offences.
Carlo Ancelotti continues the project of a 4-4-2 system after years of Maurizio Sarri’s tried and tested 4-3-3, also embracing the kind of squad rotation that Sarri always snubbed.
Napoli are expected to drop Dries Mertens and Marek Hamsik in favour of Aradkiusz Milik and Fabian Ruiz against Liverpool.
It kicks off at the Stadio San Paolo at 20.00 UK time (19.00 GMT).
The Partenopei are fresh from a narrow defeat to Juventus in the top of the Serie A table showdown, which saw Mario Rui sent off for two bookable offences.
Carlo Ancelotti continues the project of a 4-4-2 system after years of Maurizio Sarri’s tried and tested 4-3-3, also embracing the kind of squad rotation that Sarri always snubbed.
This means we are likely to see Mertens and captain Milik dropped to the bench this evening against Liverpool, with Milik and Fabian Ruiz stepping in instead.
Another option for Hamsik’s position in midfield is Amadou Diawara for a more rugged interpretation, while Piotr Zielinski and Jose Callejon should take the wings.
Vlad Chiriches, Faouzi Ghoulam and Amin Younes are all long-term injury absentees.
Liverpool are missing only Adam Lallana due to a groin injury and Jurgen Klopp is expected to use a full-strength side, despite Sunday’s upcoming Premier League title clash with Manchester City.
Last season’s Champions League Finalists have reinforced by bringing in Alisson Becker from Roma, who was briefly the most expensive goalkeeper in the world.
Naby Keita could be an option for the midfield in place of Georgino Wijnaldum.
English reporters have made much of the San Paolo's decrepit condition, but this is of no surprise to Napoli fans who have been complaining about the state of disrepair for years.
President Aurelio De Laurentiis repeatedly referred to the arena as "a toilet" and is engaged in a bitter legal battle with the local council – which owns the stadium – over who will pay for repairs.
Probable line-ups
Napoli: Ospina; Hysaj, Albiol, Koulibaly, Mario Rui; Callejon, Allan, Fabian Ruiz, Zielinski; Insigne, Milik
Napoli bench: Karnezis, Malcuit, Maksimovic, Hamsik, Diawara, Verdi, Mertens
Liverpool: Alisson; Alexander-Arnold, Gomez, Van Dijk, Robertson; Milner, Wijnaldum, Keita; Salah, Firmino, Mane
Liverpool bench: Mignolet, Moreno, Matip, Fabinho, Henderson, Sturridge, Shaqiri