Milan have Olivier Giroud back with Rafael Leao, while Roma are expected to have Paulo Dybala on the bench and a reshuffled defence in their Serie A showdown.
It kicks off at the Stadio Olimpico on Saturday at 17.00 UK time (16.00 GMT).
These two teams are locked together on 56 points and if they finish level, then their position will be decided by the head-to-head record.
Seeing as their other meeting this season ended 2-2 in January, that makes tomorrow’s result even more crucial in the battle for a top four position.
Jose Mourinho has huge problems to deal with, as Chris Smalling, Diego Llorente and Rick Karsdorp are all out of action in defence, so there are precious few options to choose from.
Dybala remains a major doubt after spraining his left ankle in the defeat to Atalanta on Monday evening, but he could be on the bench along with Gini Wijnaldum.
As for the strikers, Andrea Belotti is currently the favourite ahead of Tammy Abraham, supported by Lorenzo Pellegrini and ex-Milan man Stephan El Shaarawy.
The Rossoneri beat Lecce 2-0 last week without injured Giroud, but the France international should be back in the starting XI.
Rafael Leao’s presence is to be taken for granted, especially against a makeshift Roma defence, but Alexis Saelemaekers is pushing Brahim Diaz for the other role in the trident attack.
As the Giallorossi are notoriously strong in the air and on set plays, Simon Kjaer is the favourite ahead of Malick Thiaw.
Probable line-ups
Roma (3-4-2-1): Rui Patricio; Mancini, Kumbulla, Ibañez; Zalewski, Cristante, Matic, Spinazzola; Pellegrini, El Shaarawy; Belotti
Milan (4-2-3-1): Maignan; Calabria, Kjaer, Tomori, Theo Hernandez; Tonali, Krunic; Brahim Diaz, Bennacer, Leao; Giroud