Roma have the chance to close up within a point of leaders Juventus with Kevin Strootman starting, but Sassuolo are unbeaten in seven.
It kicks off at 17.00 GMT, click here for a match preview.
Last night Juve were held to a 0-0 draw by Fiorentina, so a victory would cut the advantage to just one point.
Roma have the chance to close up within a point of leaders Juventus with Kevin Strootman starting, but Sassuolo are unbeaten in seven.
It kicks off at 17.00 GMT, click here for a match preview.
Last night Juve were held to a 0-0 draw by Fiorentina, so a victory would cut the advantage to just one point.
However, Rudi Garcia faces a double threat in this match, as Sassuolo are on a club record seven-round unbeaten run and the Giallorossi risk distraction from Wednesday’s Champions League showdown with Manchester City.
Francesco Totti, Gervinho, Douglas Maicon, Davide Astori and Radja Nainggolan are rested, while Vasilis Torosidis, Federico Balzaretti and Leandro Castan are unavailable.
Strootman gets his first start since snapping the anterior cruciate ligament in his knee back in March, while Juan Manuel Iturbe is also eager to make his mark.
Sassuolo have hit form and climbed clear of the danger zone after seven games unbeaten, while this is a familiar stadium for their Coach – ex-Roma midfielder Eusebio Di Francesco.
Francesco Magnanelli is suspended, joining the injured Gianluca Pegolo and Thomas Manfredini.
Simone Zaza returns from his ban to complete the trident with Nicola Sansone and Domenico Berardi.
Roma: De Sanctis; Florenzi, Manolas, Yanga-Mbiwa, Holebas; Pjanic, De Rossi, Strootman; Iturbe, Destro, Ljajic
Roma bench: Skorupski; Cole, Emanuelson, Maicon, Somma, Astori, Keita, Nainggolan, Totti, Gervinho, Borriello, Sanabria
Sassuolo: Consigli; Vrsaljko, Cannavaro, Acerbi, Peluso; Brighi, Missiroli, Taider; Berardi, Zaza, Sansone
Sassuolo bench: Pomini, Polito; Antei, Ariaudo, Terranova, Longhi, Gazzola, Biondini, Chibsah, Pavoletti, Floccari, Floro Flores