Edin Dzeko is in the starting XI with Stephan El Shaarawy, as Patrik Schick misses out with a muscular problem against Sampdoria.
It kicks off at 19.45 GMT, follow the build-up and action as it happens on the LIVEBLOG.
There are only a few days left until the January transfer deadline and until then, the situation for Dzeko and Emerson Palmieri will remain in the balance amid Chelsea negotiations.
Edin Dzeko is in the starting XI with Stephan El Shaarawy, as Patrik Schick misses out with a muscular problem against Sampdoria.
It kicks off at 19.45 GMT, follow the build-up and action as it happens on the LIVEBLOG.
There are only a few days left until the January transfer deadline and until then, the situation for Dzeko and Emerson Palmieri will remain in the balance amid Chelsea negotiations.
If there was the faint possibility Schick could be chosen to lead the line this evening, that vanished when the ex-Sampdoria striker picked up yet another muscular injury in training yesterday.
Diego Perotti is back in the squad, but left on the bench with Gregoire Defrel in favour of Turkish youngster Cengiz Under.
Daniele De Rossi is still not fully fit with a calf problem, so Lorenzo Pellegrini and Kevin Strootman again join Radja Nainggolan in midfield.
Federico Fazio is rested in favour of Juan Jesus.
These teams faced off on Wednesday night, a 1-1 draw at Marassi the rescheduled Week 3 fixture originally called off in September due to heavy rain.
Fabio Quagliarella was on target in that game, but also went off with a thigh problem and is benched today, Gianluca Caprari partnering Duvan Zapata and Gaston Ramirez.
Dennis Praet is out injured for quite a while with a serious thigh strain, so Edgar Barreto and Karol Linetty join Lucas Torreira.
Roma: Alisson; Florenzi, Manolas, Juan Jesus, Kolarov; Pellegrini, Strootman, Nainggolan; Under, Dzeko, El Shaarawy
Roma bench: Skorupski, Lobont, Fazio, Moreno, Peres, Nura, Emerson, De Rossi, Gerson, Defrel, Antonucci, Perotti
Sampdoria: Viviano; Bereszynski, Silvestre, Ferrari, Murru; Barreto, Torreira, Linetty; Ramirez; Caprari, Duvan Zapata
Sampdoria bench: Puggioni, Tozzo, Andersen, Sala, Alvarez, Tomic, Strinic, Regini, Verre, Capezzi, Quagliarella, Kownacki