Roma are forced to revamp their attack, but stick with Edin Dzeko against a Fiorentina side on five consecutive victories, but without Federico Chiesa.
It kicks off at the Stadio Olimpico at 17.00 UK time (16.00 GMT).
Follow all the build-up and action as it happens from this game, SPAL-Atalanta and Sampdoria–Genoa on the LIVEBLOG.
Roma are forced to revamp their attack, but stick with Edin Dzeko against a Fiorentina side on five consecutive victories, but without Federico Chiesa.
It kicks off at the Stadio Olimpico at 17.00 UK time (16.00 GMT).
The Giallorossi find themselves at the business end of the season with two different tournaments to keep in the balance.
The 4-1 result was very harsh at Camp Nou in Wednesday’s Champions League quarter-final and that Dzeko away goal gives them some slender hope of turning it around against Barcelona next week.
At the same time, Coach Eusebio Di Francesco has to focus on ensuring a top four finish in Serie A so that Roma can play in the Champions League again next season.
Cengiz Under is still out injured and joined by Diego Perotti, while Radja Nainggolan is back in the starting XI after missing the Barca clash.
Dzeko is therefore flanked by Gregoire Defrel and Stephan El Shaarawy, while Maxime Gonalons gets a rare start in midfield.
Fiorentina are on a roll at the moment, winning five in a row and finding strength in their unity after the tragedy of losing captain Davide Astori.
He’ll be remembered at the Olimpico, because the defender did play for Roma in 2014-15 and was also teammates with Radja Nainggolan at Cagliari before that.
The Viola are now closing on Europa League places and want to keep the momentum going, but Milan Badelj is injured and star man Chiesa suspended.
Bryan Dabo steps in to midfield with Valentin Eysseric, Jordan Veretout, Marco Benassi and Riccardo Saponara supporting Giovanni Simeone.
The last time Fiorentina walked out of the Stadio Olimpico with the three points in Serie A was a 2-1 result in April 2012, followed by five consecutive defeats. In that period, however, the Viola did win here in both the Coppa Italia and Europa League.
Roma: Alisson; Peres, Manolas, Fazio, Juan Jesus; Strootman, Gonalons, Nainggolan; Defrel, Dzeko, El Shaarawy
Fiorentina: Sportiello; Laurini, Pezzella, Vitor Hugo, Biraghi; Benassi, Dabo; Veretout, Saponara, Eysseric; Simeone
Ref: Fabbri