Palermo and Milan have both stuttered of late, so seek a significant step forward at the Stadio Barbera.
It kicks off at 14.00 UK time (13.00 GMT), click here to follow our LIVEBLOG.
Pippo Inzaghi remains under pressure to qualify for Europe and may well have saved his job with a 3-1 win over Cagliari before the international break.
Palermo and Milan have both stuttered of late, so seek a significant step forward at the Stadio Barbera.
It kicks off at 14.00 UK time (13.00 GMT), click here to follow our LIVEBLOG.
Pippo Inzaghi remains under pressure to qualify for Europe and may well have saved his job with a 3-1 win over Cagliari before the international break.
His side is without an away victory since October and it’ll be tough to break that run here, where Palermo have lost only twice this season to Lazio and Juventus.
The Rosanero already caused a huge upset when winning 2-0 at San Siro back in November.
As usual, the Rossoneri have an extensive injury list including Keisuke Honda, Riccardo Montolivo, Adil Rami, Stephan El Shaarawy, Pablo Armero and Cristian Zaccardo.
Giacomo Bonaventura shakes off a shoulder injury to start with Alessio Cerci, Mattia Destro and Jeremy Menez forming the trident.
Palermo have hit the brakes recently and failed to score in their last four games, but a win would put them level on points with Milan.
Paulo Dybala will be sold after rejecting a contract renewal and has sparked a €40m bidding war between Juventus and Arsenal.
He partners Franco Vazquez, who is fresh from making his Italy debut in the 1-1 friendly draw with England.
Sinisa Andelkovic is suspended, joining Michel Morganella in the stands.
Palermo: Sorrentino; Rispoli, Gonzalez, Vitiello, Lazaar; Rigoni, Jajalo, Barreto; Vazquez, Quaison; Dybala
Milan: Diego Lopez; Abate, Paletta, Mexes, Antonelli; Van Ginkel, De Jong, Bonaventura; Cerci, Destro, Menez