Dries Mertens partners Lorenzo Insigne for Napoli, while Gianluigi Buffon makes his Champions League debut for Paris Saint-Germain.
It kicks off at the packed Stadio San Paolo at 20.00 GMT.
Follow the build-up and action as it happens from this game and Inter-Barcelona on the LIVEBLOG.
Dries Mertens partners Lorenzo Insigne for Napoli, while Gianluigi Buffon makes his Champions League debut for Paris Saint-Germain.
It kicks off at the packed Stadio San Paolo at 20.00 GMT.
Follow the build-up and action as it happens from this game and Inter-Barcelona on the LIVEBLOG.
The Partenopei had been leading twice at Parc des Princes and outplayed PSG for long periods, but were pegged back to a 2-2 draw by Angel Di Maria’s last-gasp strike from distance.
Carlo Ancelotti has fielded a different starting XI in every single match this season.
This time, Mertens is chosen as the partner to Insigne, because the Belgian couldn’t be left out after his hat-trick in Saturday’s 5-1 win over Empoli.
Fabian Ruiz and Jose Callejon give a Spanish feel to the flanks, around Allan and captain Marek Hamsik, while Nikola Maksimovic is again used in what is effectively a three-and-a-half man defence, allowing Mario Rui to push up.
Paris Saint-Germain know a defeat here could practically knock them out of the Champions League, having already lost to Liverpool and drawn at home with Napoli.
Buffon has finally finished his ban after a red card and insults to the referee when Juventus lost to Real Madrid last season, which means he gets his Champions League debut in a PSG jersey.
He is joined by fellow Italy international Verratti, who this week was charged with drink-driving in France.
Verratti was teammates with Insigne and Ciro Immobile in Serie B outfit Pescara.
Thiago Silva missed the first meeting through injury, but the former Milan defender is back in the starting XI for an unusual 3-4-3 formation.
Former Napoli star Edinson Cavani is only on the bench, as he missed this weekend’s Ligue 1 game due to a muscular issue.
The Uruguay international has been repeatedly linked with a return to Napoli and he is on the bench with Adrien Rabiot, as Neymar and Kylian Mbappé are joined by Angel Di Maria.
Napoli: Ospina; Maksimovic, Albiol, Koulibaly, Mario Rui; Callejon, Allan, Hamsik, Fabian; Insigne, Mertens
Napoli bench: Karnezis, Hysaj, Malcuit, Diawara, Zielinski, Ounas, Milik
PSG: Buffon; Kehrer, Thiago Silva, Marquinhos; Bernat, Draxler, Verratti, Meunier; Neymar, Mbappé, Di Maria
PSG bench: Areola, Kimpembe, Cavani, Choupo-Moting, Rabiot, Diaby, Nsoki