Napoli have the chance to close within three points of Roma, but first need to get past exciting Sassuolo.
It kicks off at 18.00 GMT, click here for a match preview.
The Partenopei have been on sparkling form, as shown by their 4-0 away victory over Trabzonspor in the Europa League on Thursday night.
That was almost an even heavier result, as Dries Mertens missed a penalty.
Napoli have the chance to close within three points of Roma, but first need to get past exciting Sassuolo.
It kicks off at 18.00 GMT, click here for a match preview.
The Partenopei have been on sparkling form, as shown by their 4-0 away victory over Trabzonspor in the Europa League on Thursday night.
That was almost an even heavier result, as Dries Mertens missed a penalty.
This evening top scorer Gonzalo Higuain is suspended, so Duvan Zapata gets a rare chance to show what he can do from the start.
Long-term absentees are Lorenzo Insigne, Juan Camilo Zuniga and Michu.
There is another big change in goal, as Rafa Benitez has decided the recent howlers were too much to ignore and so Rafael is dropped in favour of Mariano Andujar.
Manolo Gabbiadini can’t stop scoring at the moment, so is certainly one to watch.
As for Sassuolo, they play some of the most exciting football in Serie A and that can also make them very unpredictable.
They are fresh from defeat to Fiorentina and have never beaten Napoli in their three previous Serie A encounters.
Federico Peluso, Gianluca Pegolo, Emanuele Terranova and Sime Vrsaljko are sidelined, while Nicola Sansone is carrying an injury, so ex-Napoli striker Antonio Floro Flores starts instead.
Simone Zaza and Domenico Berardi already have big futures lined up ahead of them and are eager to shine at the Stadio San Paolo.
Of course, one man particularly eager to make his mark is Paolo Cannavaro, the former Napoli captain and hometown hero who has made it abundantly clear he blames Benitez for pushing him out of the club.
Napoli: Andujar; Maggio, Albiol, Koulibaly, Ghoulam; Gargano, David Lopez; Gabbiadini, Hamsik, Callejon; Zapata
Napoli bench: Rafael, Colombo, Mesto, Henrique, Britos, Strinic, Inler, Jorginho, Mertens, De Guzman
Sassuolo: Consigli; Antei, Cannavaro, Acerbi, Gazzola; Taider, Magnanelli, Missiroli; Berardi, Zaza, Floro Flores
Sassuolo bench: Celeste, Polito; Bianco, Chibsah, Brighi, Biondini, Donis, Sansone, Floccari, Lazarevic