Napoli rely on Manolo Gabbiadini and Nikola Maksimovic, while Roma look to Edin Dzeko and Radja Nainggolan in a showdown for second place.
It kicks off at the Stadio San Paolo at 14.00 UK time (13.00 GMT), follow the build-up and action on the LIVEBLOG.
Only one point separates the two sides going into the Derby del Sole and the winner will emerge as the most likely Scudetto contender for leaders Juventus.
Napoli rely on Manolo Gabbiadini and Nikola Maksimovic, while Roma look to Edin Dzeko and Radja Nainggolan in a showdown for second place.
It kicks off at the Stadio San Paolo at 14.00 UK time (13.00 GMT), follow the build-up and action on the LIVEBLOG.
Only one point separates the two sides going into the Derby del Sole and the winner will emerge as the most likely Scudetto contender for leaders Juventus.
Both Coaches are forced into some tactical reshuffles by an injury crisis following the break for international duty.
Arkadiusz Milik is out for four to six months after the complete rupture of his anterior cruciate ligament while playing for Poland.
While Dries Mertens and Jose Callejon were floated as False 9 options, the keys to the attack are handed to Gabbiadini, flanked by Lorenzo Insigne.
Raul Albiol is also injured in defence, so Maksimovic partners Kalidou Koulibaly in the centre.
Roma also have issues to deal with, as Kevin Strootman (back pain) and Bruno Peres (muscular) haven’t even made the trip due to injuries, joining long-term absentees Mario Rui, Antonio Rudiger and Thomas Vermaelen.
Nainggolan isn’t 100 per cent fit either and missed out on international duty with Belgium last week because of it, but must grit his teeth and start in a 4-2-3-1 system.
He supports centre-forward Edin Dzeko with Mohamed Salah and Diego Perotti, while Alessandro Florenzi – also not at his best – moves to right-back.
Napoli: Reina; Hysaj, Maksimovic, Koulibaly, Ghoulam; Allan, Jorginho, Hamsik; Callejon, Gabbiadini, Insigne
Napoli bench: Sepe, Rafael, Maggio, Chiriches, Strinic, Zielinski, Tonelli, Diawara, Giaccherini, Rog, Mertens, El Kaddouri
Roma: Szczesny; Florenzi, Manolas, Fazio, Juan Jesus; De Rossi, Paredes; Salah, Nainggolan, Perotti; Dzeko
Roma bench: Alisson, Marchizza, Emerson Palmieri, Seck, Gerson, Totti, Iturbe, El Shaarawy