Napoli rely on Hirving Lozano, Arkadiusz Milik and Lorenzo Insigne in the face-off for third place with Atalanta, who have Josip Ilicic as a False 9.
It kicks off at the Stadio San Paolo at 18.00 GMT.
This is a head-to-head for position, as a victory would put Napoli level on 20 points with Atalanta in third place.
Napoli rely on Hirving Lozano, Arkadiusz Milik and Lorenzo Insigne in the face-off for third place with Atalanta, who have Josip Ilicic as a False 9.
It kicks off at the Stadio San Paolo at 18.00 GMT.
This is a head-to-head for position, as a victory would put Napoli level on 20 points with Atalanta in third place.
Gian Piero Gasperini’s men are proving to be no mere flash in the pan, as after securing third last season and their first ever Champions League qualification, they are doing even better in Serie A this time around.
They went into the midweek round just three points off leaders Juventus and have shattered records with 28 goals in the opening nine games, thanks also to last week’s 7-1 thrashing of Udinese.
Napoli, meanwhile, have impressed in Europe, but already lost two Serie A games and missed an opportunity to close on the leaders when held by SPAL on Sunday.
Kevin Malcuit suffered a season-ending knee injury, while Kostas Manolas, Elseid Hysaj and Faouzi Ghoulam are also still out, leaving a shortage of defenders.
Nikola Maksimovic returns just in time, with Mario Rui not fully fit after his injury, so Sebastiano Luperto is moved over to left-back.
Insigne and Jose Callejon take the traditional wide roles, with misfiring Hirving Lozano given another chance over Dries Mertens, the Mexican partnering Arkadiusz Milik up top.
Atalanta are still without Duvan Zapata but, just as with Manchester City, Luis Muriel is not used from the start, preserved to make an impact off the bench.
Instead, Ilicic becomes the False 9, supported by Papu Gomez and Mario Pasalic, while Jose Luis Palomino and Andrea Masiello return in defence.
Only Manchester City (12) have won more away fixtures in the top five European leagues than Atalanta (10) in 2019.
Napoli: Meret; Di Lorenzo, Maksimovic, Koulibaly, Luperto; Callejon, Allan, Fabian, Insigne; Milik, Lozano
Atalanta: Gollini; Toloi, Palomino, Djimsiti; Hateboer, De Roon, Freuler, Gosens; Pasalic, Gomez; Ilicic
Ref: Giacomelli