Milan again start Krzysztof Piatek and Samu Castillejo, but revamp their midfield, as Lazio try to end their 30-year San Siro taboo.
It kicks off at 19.45 GMT, you can follow all the build-up and action as it happens on the LIVEBLOG.
Stefano Pioli registered his first win since replacing Marco Giampaolo, as Suso came off the bench to curl in a free kick in the 1-0 win over SPAL on Thursday.
Milan again start Krzysztof Piatek and Samu Castillejo, but revamp their midfield, as Lazio try to end their 30-year San Siro taboo.
It kicks off at 19.45 GMT, you can follow all the build-up and action as it happens on the LIVEBLOG.
Stefano Pioli registered his first win since replacing Marco Giampaolo, as Suso came off the bench to curl in a free kick in the 1-0 win over SPAL on Thursday.
Suso was expected to start this evening, but pulled out of the squad with a hip injury, joining defender Mateo Musacchio on the treatment table.
Ricardo Rodriguez and Mattia Caldara return for a spot on the bench, but Leo Duarte and Samu Castillejo again start.
Piatek is chosen to lead the line rather than Rafael Leao, but the biggest changes are in midfield with Ismael Bennacer and Rade Krunic joining Lucas Paqueta.
Franck Kessie has looked rusty of late and is sent to the touchline.
Lazio have a full squad to choose from and are brimming with confidence after a midweek 4-0 mauling of Torino.
Manuel Lazzari retains his spot ahead of Adam Marusic on the wing, while Joaquin Correa gets the nod rather than Felipe Caicedo.
Ciro Immobile is Capocannoniere with 12 goals in 10 rounds and only one strike off his century in a Lazio jersey.
The Biancocelesti won here last season in the Coppa Italia semi-final, but have not earned a Serie A victory away to Milan since Paolo Maldini’s own goal in 1989.
Milan: G Donnarumma; Calabria, Duarte, Romagnoli, Theo Hernandez; Paqueta, Bennacer, Krunic; Castillejo, Piatek, Calhanoglu
Lazio: Strakosha; Bastos, Acerbi, Radu; Lazzari, Milinkovic-Savic, Leiva, Luis Alberto, Lulic; Correa, Immobile