Milan can close on the Champions League places as they host a Sassuolo side struggling to escape the drop zone.
It kicks off at 19.45 UK time (18.45 GMT), follow the build-up and action as it happens on the LIVEBLOG.
The Rossoneri have benefited from several results this weekend in their hopes of a top four finish, as Roma and Inter both lost, while Atalanta and Sampdoria were held to draws.
Milan can close on the Champions League places as they host a Sassuolo side struggling to escape the drop zone.
It kicks off at 19.45 UK time (18.45 GMT), follow the build-up and action as it happens on the LIVEBLOG.
The Rossoneri have benefited from several results this weekend in their hopes of a top four finish, as Roma and Inter both lost, while Atalanta and Sampdoria were held to draws.
A win would close the gap from Inter in fourth place to five points, albeit only increasing regret at the midweek stalemate against their city rivals.
Gennaro Gattuso signed a new contract to June 2021, but at the same time must also look over his shoulder, as Fiorentina are only one point behind them now after six wins on the bounce.
Lucas Biglia returns from suspension in midfield, sending Riccardo Montolivo to the bench, while Patrick Cutrone gets the nod ahead of Andre Silva and Nikola Kalinic.
It was later revealed Andre Silva missed the midweek derby because of a family bereavement after fans asked why he hadn’t come off the bench.
Davide Calabria is a late injury addition, so Ignazio Abate steps in at right-back for his first start since February 10, while Hakan Calhanoglu has shaken off a knock.
Sassuolo are in genuine danger of relegation, as they are on 29 points – with this game in hand – alongside Chievo and Cagliari, only two points clear of the bottom three.
Francesco Magnanelli and Claud Adjapong sit out bans after their red cards in the midweek rescheduled round, but despite going down to nine men, they still snatched a point in stoppages away to Chievo.
Francesco Cassata’s long free kick went past everyone to surprise Stefano Sorrentino at the 95th minute.
The big question mark for Beppe Iachini related to Domenico Berardi, who required a late fitness test for this match, but he is in the starting XI with Matteo Politano.
Berardi loves facing Milan, as in just eight meetings, he scored eight goals and provided three assists.
Sassuolo have beaten Milan four times in the last five seasons, so are not to be underestimated at San Siro.
These sides have never shared the spoils, with five Rossoneri victories and four for the Neroverdi, home and away.
Milan: G Donnarumma; Abate, Bonucci, Romagnoli, Rodriguez; Kessie, Biglia, Bonaventura; Suso, Cutrone, Calhanoglu
Milan bench: A Donnarumma, Storari, Zapata, Musacchio, Antonelli, Montolivo, Mauri, Locatelli, Borini, Andre Silva, Kalinic
Sassuolo: Consigli; Lemos, Acerbi, Peluso; Lirola, Mazzitelli, Sensi, Missiroli, Rogerio; Berardi, Politano
Sassuolo bench: Pegolo, Marson, Biondini, Matri, Pierini, Frattesi, Cassata, Babacar, Duncan, Dell’Orco, Ragusa