Milan have precious few options to choose from, as Diogo Dalot, Fikayo Tomori and Rafael Leao start against Bruno Fernandes’ Manchester United.
The Europa League Round of 16 first leg kicks off at Old Trafford at 17.55 GMT.
You can follow all the build-up and action as it happens from this game and Roma-Shakhtar Donetsk on the LIVEBLOG.
Milan have precious few options to choose from, as Diogo Dalot, Fikayo Tomori and Rafael Leao start against Bruno Fernandes’ Manchester United.
The Europa League Round of 16 first leg kicks off at Old Trafford at 17.55 GMT.
The Rossoneri have a decimated squad yet again for this trip to England, missing Zlatan Ibrahimovic, Mario Mandzukic, Hakan Calhanoglu, Theo Hernandez, Ismael Bennacer and with Alessio Romagnoli suffering from a bruised foot.
It means Dalot has to face his parent club at left-back, with Chelsea loanee Tomori partnering Simon Kjaer. There are only five outfield players on the bench.
Brahim Diaz steps into the trequartista role, moving Rade Krunic over to the left, with Alexis Saelemaekers also supporting to only available striker, Rafael Leao.
Manchester United have issues too, as they are without David De Gea, Donny van de Beek, Paul Pogba, Marcus Rashford and Juan Mata, while former Napoli striker Edinson Cavani is not fully fit either.
The star man to keep an eye on is Bruno Fernandes, formerly of Sampdoria and Pescara, who has single-handedly transformed their fortunes since his arrival.
He starts with Daniel James and Mason Greenwood supporting Anthony Martial.
Former Atalanta teenage talent Amad Diallo is on the bench.
These clubs have met 10 times before, but they were always in the Champions League or European Cup.
Milan knocked Manchester United out in four of the five knockout ties.
The second leg is at San Siro on March 18. Gianluigi Donnarumma, Alessio Romagnoli, Victor Lindelof, Harry Maguire and Brandon Williams are one yellow card away from suspension.
Manchester United: Henderson; Wan-Bissaka, Bailly, Maguire, Telles; McTominay, Matic, Bruno Fernandes; James, Greenwood, Martial
Man Utd bench: Grant, Bishop, Lindelof, Fred, Diallo, Shaw, B Williams, Tuanzebe, Shoretire
Milan: G Donnarumma; Calabria, Kjaer, Tomori, Dalot; Meite, Kessie; Saelemaekers, Brahim Diaz, Krunic; Leao
Milan bench: Tatarusanu, A Donnarumma, Castillejo, Tonali, Kalulu, Tonin, Gabbia
Ref: Vincic (SVN)