Lazio and Napoli are separated by just one point and go head-to-head for third place in the early game.
It kicks off at the Stadio Olimpico at 11.30 GMT, click here for a match preview.
This round represents the halfway stage of the Serie A season, so being in that third Champions League spot would be a real psychological boost to either club.
Lazio hold that position at the moment despite an epic injury crisis that added more names over the last few days.
Lazio and Napoli are separated by just one point and go head-to-head for third place in the early game.
It kicks off at the Stadio Olimpico at 11.30 GMT, click here for a match preview.
This round represents the halfway stage of the Serie A season, so being in that third Champions League spot would be a real psychological boost to either club.
Lazio hold that position at the moment despite an epic injury crisis that added more names over the last few days.
Federico Marchetti is suspended, so Albania international Etrit Berisha goes in goal.
Stefano Mauri and Felipe Anderson were late additions to the absentee list, joining Stefan de Vrij, Michael Ciani, Ederson, Alvaro Gonzalez, Santiago Gentiletti and Edson Braafheid.
It means Keita Balde Diao finally gets a chance to shine this season, having been largely relegated to the bench by Coach Stefano Pioli.
The talented youngster partners Antonio Candreva and Filip Djordjevic in attack, with Miroslav Klose ready to come off the bench.
Napoli are still furious after their 3-1 defeat to Juventus and Coach Rafa Benitez further stoked controversy with comments about referees.
The fact remains the Partenopei must channel that rage into positive energy to get a result at the Olimpico.
Miguel Angel Britos is suspended, so January signing Ivan Strinic is thrown straight into the starting XI for his debut.
Manolo Gabbiadini is on the bench, but Dries Mertens is given the nod along with Jonathan de Guzman, Jose Callejon and hitman Gonzalo Higuain.
That means Marek Hamsik is surprisingly dropped to the bench.
Faouzi Ghoulam is at the Africa Cup of Nations, while Juan Camilo Zuniga, Michu and Lorenzo Insigne remain on the treatment table.
Lazio have won this fixture on nine of the last 14 occasions. However, since Benitez took charge in 2013 his Napoli beat the Aquile every time.
Lazio: Berisha; Basta, Cana, Radu, Cavanda; Biglia, Ledesma, Parolo; Candreva, Djordjevic, Keita
Lazio bench: Strakosha, Guerrieri, Pereirinha, Konko, Novaretti, Cataldi, Onazi, Tounkara, Klose
Napoli: Rafael; Maggio, Albiol, Koulibaly, Strinic; Gargano, David Lopez; Callejon, De Guzman, Mertens; Higuain
Napoli bench: Andujar, Colombo, Mesto, Jorginho, Henrique, Hamsik, Inler, Gabbiadini, Duvan Zapata