Andrea Pirlo makes his coaching debut with some very surprising changes, starting Weston McKennie, Dejan Kulusevski and Gianluca Frabotta against Sampdoria.
It kicks off in Turin at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
Andrea Pirlo makes his coaching debut with some very surprising changes, starting Weston McKennie, Dejan Kulusevski and Gianluca Frabotta against Sampdoria.
It kicks off in Turin at 19.45 UK time (18.45 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
Pirlo has his first ever game as a coach, having earned his badges only a few days ago, and is up against Claudio Ranieri, who today marks his 400th Serie A match.
Il Maestro is thrown in at the deep end with a team seeking its 10th consecutive Scudetto, replacing sacked Maurizio Sarri, and he switches to a 3-4-3 formation.
Paulo Dybala, Matthijs de Ligt, Alex Sandro and Federico Bernardeschi are out injured, so after Gonzalo Higuain left for Inter Miami and with problems holding up Edin Dzeko’s move from Roma, the Bianconeri have no centre-forwards.
Instead, Cristiano Ronaldo and newcomer Kulusevski lead the way, with Juan Cuadrado and 21-year-old Frabotta on the wings, Luca Pellegrini not even on the bench ahead of a probable Genoa loan.
Frabotta has made only one previous Serie A appearance, last season's closing 3-1 home defeat to Roma.
McKennie also gets a surprising start after his transfer from Schalke 04, with Aaron Ramsey seemingly in a wider role supporting Ronaldo.
Danilo completes the three at the back in a more central role than he is accustomed to.
Sampdoria are missing Manolo Gabbiadini and suspended Kristoffer Askildsen, so Federico Bonazzoli is the lone centre-forward, leaving Fabio Quagliarella on the bench.
There are no new signings in the starting XI, as Samp try to build on the good form with which they finished last season.
Since Juventus started their winning streak in 2011-12, they have lost four Serie A games against Sampdoria. The only opponent the Bianconeri suffered more defeats against during that period was Roma on five.
However, Sampdoria’s last top flight away win at Juve was in January 2013, with Mauro Icardi’s brace in a 2-1 result.
Juventus: Szczesny; Bonucci, Chiellini, Danilo; Cuadrado, Rabiot, McKennie, Frabotta; Kulusevski, Cristiano Ronaldo, Ramsey
Sampdoria: Audero; Bereszynski, Tonelli, Colley, Augello; Depaoli, Thorsby, Ekdal, Leris, Jankto; Bonazzoli
Ref: Piccinini