Juventus put Miralem Pjanic in a new trequartista role as they start Claudio Marchisio in a 4-3-1-2 against Alexandre Lacazette’s Lyon.
It kicks off in Turin at 19.45 GMT, follow the build-up and action on the LIVEBLOG.
A fortnight ago the Bianconeri won 1-0 on French soil with a Juan Cuadrado stunner, but Mario Lemina was sent off and is therefore suspended.
Juventus put Miralem Pjanic in a new trequartista role as they start Claudio Marchisio in a 4-3-1-2 against Alexandre Lacazette’s Lyon.
It kicks off in Turin at 19.45 GMT, follow the build-up and action on the LIVEBLOG.
A fortnight ago the Bianconeri won 1-0 on French soil with a Juan Cuadrado stunner, but Mario Lemina was sent off and is therefore suspended.
Paulo Dybala, Marko Pjaca and Giorgio Chiellini are injured, so Marchisio gets his first Champions League start since February, having been out for six months with a torn ACL.
Stefano Sturaro also gets a rare outing and Max Allegri transforms his team into a 4-3-1-2 with Pjanic in the hole behind Mario Mandzukic and Gonzalo Higuain.
Gigi Buffon silenced many critics with his heroics in Lyon and could well be called into action again tonight if the new system takes a while to bed in.
It’s a very special night for the goalkeeper, who makes his 100th Champions League appearance, not including qualifying rounds.
Lyon miss Mathieu Valbuena and Christophe Jallet, but Nicolas Nkoulou is back in the squad.
Bruno Genesio’s side have struggled so far this season, both in Europe and domestically, but received a boost at the weekend when winning 2-1 in Toulouse.
Lacazette scored both their goals in that match, but they move to 4-4-2 and have Emanuel Mammana back after he missed the first leg with flu.
Juventus lost only one Champions League game at their new stadium, winning 11, but it’s worth noting that in 2016 they’ve only had draws against Bayern Munich and Sevilla.
Juventus: Buffon; Dani Alves, Bonucci, Barzagli, Evra; Khedira, Marchisio, Sturaro; Pjanic; Mandzukic, Higuain
Juventus bench: Neto, Benatia, Rugani, Alex Sandro, Hernanes, Cuadrado, Kean
Lyon: Lopes; Rafael, Diakhaby, Mammana, Morel; Ghezzal, Gonalons, Tolisso, Rybus; Fekir, Lacazette
Lyon bench: Gorgelin, Yanga-Mbiwa, Grenier, Ferri, Darder, Cornet, Tousart