Juventus give Paulo Dybala a new centre-forward role flanked by Federico Bernardeschi and Douglas Costa in the Coppa Italia against Genoa.
It kicks off at the Allianz Juventus Stadium in Turin at 19.45 GMT and the winners go through to face Torino in the quarter-final on January 3.
The Bianconeri are looking to retain the trophy, but Max Allegri is missing injured Gigi Buffon, Mario Mandzukic and Juan Cuadrado.
Juventus give Paulo Dybala a new centre-forward role flanked by Federico Bernardeschi and Douglas Costa in the Coppa Italia against Genoa.
It kicks off at the Allianz Juventus Stadium in Turin at 19.45 GMT and the winners go through to face Torino in the quarter-final on January 3.
The Bianconeri are looking to retain the trophy, but Max Allegri is missing injured Gigi Buffon, Mario Mandzukic and Juan Cuadrado.
Giorgio Chiellini and Stephan Lichtsteiner are not 100 per cent fit, but the full-back starts anyway, with Rodrigo Bentancur and Claudio Marchisio taking the midfield roles.
Dybala has been dropped for the last two Serie A games, but returns in a new role to suit the 4-3-3 formation, as a False 9 supported by Bernardeschi and Douglas Costa.
Genoa have Giuseppe Rossi on the bench for the first time since he signed as a free agent, as his international transfer finally came through this week.
Coach Davide Ballardini makes numerous changes, using Ricardo Centurion as the striker with Andrej Galabinov and Diego Laxalt.
Juventus: Szczesny; Lichtsteiner, Barzagli, Rugani, Asamoah; Marchisio, Bentancur, Sturaro; Douglas Costa, Dybala, Bernardeschi
Juventus bench: Pinsoglio, Loria, Chiellini, Benatia, Alex Sandro, Khedira, Matuidi, Pjanic, Pjaca, Higuain
Genoa: Lamanna; Biraschi, Rossettini, Gentiletti; Lazovic, Omeonga, Cofie, Brlek; Laxalt, Centurion, Galabinov
Genoa bench: To follow