Juventus are forced to reshuffle with Daniele Rugani, Roberto Pereyra and Claudio Marchisio against Riccardo Saponara’s Empoli.
It kicks off at 19.45 UK time (18.45 GMT), follow the build-up and action on our LIVEBLOG.
The Bianconeri are top of the Serie A table, but return from international duty with a decimated squad.
Leonardo Bonucci, Alex Sandro and Sami Khedira are all suspended, while Paulo Dybala and Martin Caceres are injured.
Juventus are forced to reshuffle with Daniele Rugani, Roberto Pereyra and Claudio Marchisio against Riccardo Saponara’s Empoli.
It kicks off at 19.45 UK time (18.45 GMT), follow the build-up and action on our LIVEBLOG.
The Bianconeri are top of the Serie A table, but return from international duty with a decimated squad.
Leonardo Bonucci, Alex Sandro and Sami Khedira are all suspended, while Paulo Dybala and Martin Caceres are injured.
The good news for Max Allegri is that Giorgio Chiellini and Marchisio are back in action following muscular problems.
Rugani is given the chance to shine against his old club alongside Andrea Barzagli – who also pulled out of international duty with an injury.
Pereyra is chosen to bolster the midfield, while Alvaro Morata partners Mario Mandzukic in an unusually bulky attack.
Empoli have been in poor form recently, without a win in the last 11 rounds, including six defeats, keeping just one clean sheet in that run.
Manuel Pucciarelli partners veteran Massimo Maccarone, who opened the scoring when Juve beat Empoli 3-1 in November.
Vincent Laurini and Marko Livaja are ruled out by injury, so Luca Bittante starts at right-back.
Empoli have defeated Juve only once in their last 13 competitive meetings, a 2-1 Coppa Italia result in December 2007.
There was a 0-0 stalemate in 2008 and a spectacular 3-3 draw in 2004, but the most recent Serie A victory was 1-0 in April 1999.
The Tuscans do not have a good record in Turin, managing one point from nine Serie A visits, scoring four goals and conceding 25.
Juventus: Buffon; Barzagli, Rugani, Chiellini; Lichtsteiner, Pereyra, Marchisio, Pogba, Evra; Morata, Mandzukic
Juventus bench: Neto, Rubinho, Romagna, Padoin, Lemina, Sturaro, Hernanes, Asamoah, Cuadrado, Zaza
Empoli: Skorupski; Bittante, Tonelli, Costa, Mario Rui; Zielinski, Paredes, Buchel; Saponara; Pucciarelli, Maccarone
Empoli bench: Pugliesi, Pelagotti, Zambelli, Croce, Maiello, Diousse, Piu, Cosic, Camporese, Krunic