Roberto Mancini rings the changes again with the Netherlands, starting Simone Verdi, Bryan Cristante, Andrea Belotti and Mattia Perin.
It kicks off at the Juventus Stadium in Turin at 19.45 UK time (18.45 GMT).
Follow the build-up and action while giving your views on the LIVEBLOG.
The Azzurri continue their reconstruction under new CT Mancini, who revamped his side for the 2-1 win over Saudi Arabia and 3-1 defeat to France.
Roberto Mancini rings the changes again with the Netherlands, starting Simone Verdi, Bryan Cristante, Andrea Belotti and Mattia Perin.
It kicks off at the Juventus Stadium in Turin at 19.45 UK time (18.45 GMT).
Follow the build-up and action while giving your views on the LIVEBLOG.
The Azzurri continue their reconstruction under new CT Mancini, who revamped his side for the 2-1 win over Saudi Arabia and 3-1 defeat to France.
Mario Balotelli started both those games, but he is on the bench this evening in favour of Torino striker Belotti.
He is flanked by Bologna winger Verdi, on the verge of a move to Napoli, with Lorenzo Insigne as captain on his 27th birthday.
Atalanta’s Bryan Cristante is given a chance to shine, with Milan’s Alessio Romagnoli and Jack Bonaventura stepping in.
Mattia Perin is given the gloves for the third different goalkeeper in three friendly games, as Gianluigi Donnarumma faced Saudi Arabia and Salvatore Sirigu started in France on Friday.
It’s a very special occasion for Genoa shot-stopper Perin, as he is in advanced talks for a transfer to Juventus and will therefore call this arena his home.
Italy haven’t qualified for the 2018 World Cup, but neither have the Netherlands, who are similarly reconstructing their national team after bitter disappointment.
Ronald Koeman has several Serie A based players in his side, including new Inter defender Stefan de Vrij and Atalanta pair Marten De Roon and Hans Hateboer.
Manchester United full-back Danny Blind has been repeatedly linked with the Nerazzurri.
Holland have never won on Italian soil, managing just two draws from eight visits.
Italy: Perin; Zappacosta, Rugani, Romagnoli, Criscito; Cristante, Jorginho, Bonaventura; Verdi, Belotti, Insigne
Italy bench: Donnarumma, De Sciglio, Bonucci, Caldara, Baselli, Mandragora, Pellegrini, Balotelli, Chiesa, Politano, Zaza, Berardi
Netherlands: Cillessen; Hateboer, De Ligt, Van Dijk, Blind; De Roon, Vormer, Wijnaldum; Babel, Depay, Vilhena
Netherlands bench: Zoet, Janmaat, De Vrij, Ake, Propper, Berghuis, Promes, Weghorst, Strootman, Kongolo, Elia, Padt