Inter start Stefano Sensi and Diego Godin with Romelu Lukaku and Lautaro Martinez, as Atalanta relaunch the trio of Duvan Zapata, Josip Ilicic and Papu Gomez.
It kicks off at San Siro at 19.45 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
Inter start Stefano Sensi and Diego Godin with Romelu Lukaku and Lautaro Martinez, as Atalanta relaunch the trio of Duvan Zapata, Josip Ilicic and Papu Gomez.
It kicks off at San Siro at 19.45 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
Antonio Conte’s men are joint leaders with Juventus going into this weekend, which marks the midway point in the Serie A season, so the Winter Champion will be decided over the next few hours.
Inter are forced into changes, because Stefan de Vrij and Nicolò Barella are suspended, with Danilo D’Ambrosio and Kwadwo Asamoah injured.
It means Godin returns to the three-man defence, with Sensi making his first start since picking up an injury in early October, as Matias Vecino is not 100 per cent fit.
Roberto Gagliardini and Alessandro Bastoni get to face their old club, being products of the Atalanta youth academy.
Romelu Lukaku and Lautaro Martinez look unstoppable at the moment, scoring 30 goals between them this season in Serie A and the Champions League.
Atalanta are not to be underestimated, as they have rediscovered their Serie A form since securing a spot in the Champions League Round of 16, where they will host Valencia at San Siro next month.
This has been their home stadium throughout the European competition, so Inter’s advantage of playing here will be lessened.
La Dea are also top scorers in Serie A this season with 48 goals after 18 rounds, more than any club at this stage since Fiorentina in 1958-59, and fresh off back-to-back 5-0 victories over Milan and Parma.
Gian Piero Gasperini finally has a full squad to choose from, as Duvan Zapata made his comeback off the bench after three months out with a thigh injury.
Duvan Zapata is thrown into the starting XI for the first time since October, completing the all-star trident with Ilicic and Papu Gomez.
Atalanta are unbeaten in their last three meetings with Inter, a pair of 0-0 draws and a 4-1 triumph in Bergamo. However, their last away victory was 2-1 in March 2014, followed by four straight defeats and last season’s stalemate.
Inter: Handanovic; Godin, De Vrij, Bastoni; Candreva, Gagliardini, Brozovic, Sensi, Biraghi; R Lukaku, Lautaro Martinez
Inter bench: Padelli, Berni, Ranocchia, Dimarco, Lazaro, Borja Valero, Vecino, Politano, Alexis Sanchez, Esposito
Atalanta: Gollini; Toloi, Palomino, Djimsiti; Hateboer, De Roon, Pasalic, Gosens; Gomez; Ilicic, Duvan Zapata
Atalanta bench: Sportiello, Rossi, Masiello, Muriel, Freuler, Piccoli, Malinovskyi, Da Riva, Castagne, Okoli, Traore, Heidenreich
Ref: Rocchi