Inter and Milan face off in the Derby della Madonnina with Mateo Kovacic and Mauro Icardi against Suso and Jeremy Menez.
It kicks off at 19.45 UK time (18.45 GMT), click here to follow our LIVEBLOG.
This fixture becomes the turning point for both clubs, as they seem increasingly unlikely to qualify for Europe and the main draw now is local pride.
Inter and Milan face off in the Derby della Madonnina with Mateo Kovacic and Mauro Icardi against Suso and Jeremy Menez.
It kicks off at 19.45 UK time (18.45 GMT), click here to follow our LIVEBLOG.
This fixture becomes the turning point for both clubs, as they seem increasingly unlikely to qualify for Europe and the main draw now is local pride.
Milan President Silvio Berlusconi held a team talk yesterday, telling his players the winner of the derby will “see the light,” whereas the losing side will be plunged into a full-blown crisis.
Fredy Guarin and Marcelo Brozovic are banned, while Dodo, Zdravko Kuzmanovic, Jonathan and Hugo Campagnaro are injured.
Xherdan Shaqiri was dropped last week after some disappointing performances and is again left out in favour of Kovacic.
Hernanes, Gary Medel and teenager Assane Gnoukouri also get the nod, a shock first Serie A start for the 18-year-old after he made his debut as a substitute against Verona for just 12 minutes.
Juan Jesus is again used as a left-back, while Rodrigo Palacio and Mauro Icardi lead the attack.
Pippo Inzaghi has to do without Riccardo Montolivo, Stephan El Shaarawy, Michael Essien, Sulley Muntari and Michael Agazzi.
Diego Lopez sprained a finger in training on Friday, but starts in goal anyway.
The big changes are the introduction of ex-Liverpool winger Suso, getting his first Serie A start after impressing in a few substitute appearances.
Keisuke Honda is still not 100 per cent fit, so Suso completes the attack with Jeremy Menez and Giacomo Bonaventura.
Alessio Cerci, who had been on the verge of joining Inter before he opted for Milan in January, is on the bench.
There are also adjustments at the back, where Alex is preferred to Gabriel Paletta.
Inter: Handanovic; D'Ambrosio, Ranocchia, Vidic, Juan Jesus; Kovacic, Medel, Gnoukouri; Hernanes; Icardi, Palacio
Inter bench: Carrizo, Andreolli, Santon, Felipe, Nagatomo, Dimarco, Obi, Palazzi, Shaqiri, Podolski, Puscas, Bonazzoli
Milan: Diego Lopez; Abate, Alex, Mexes, Antonelli; Poli, De Jong, Van Ginkel; Suso, Menez, Bonaventura
Milan bench: Abbiati, Donnarumma, Paletta, Bonera, De Sciglio, Rami, Zapata, Mastalli, Cerci, Honda, Destro, Pazzini