Lukas Podolski gets his first Inter start and Xherdan Shaqiri is on the bench as they host Gian Piero Gasperini’s high-flying Genoa.
It kicks off at 11.30 GMT, click here for a match preview.
Podolski already made his debut as a substitute in the 1-1 draw with Juventus on Tuesday evening, but is thrown into the starting XI for his first match at the Stadio Giuseppe Meazza.
Lukas Podolski gets his first Inter start and Xherdan Shaqiri is on the bench as they host Gian Piero Gasperini’s high-flying Genoa.
It kicks off at 11.30 GMT, click here for a match preview.
Podolski already made his debut as a substitute in the 1-1 draw with Juventus on Tuesday evening, but is thrown into the starting XI for his first match at the Stadio Giuseppe Meazza.
New buy Shaqiri completed his transfer from Bayern Munich on Friday and is on the bench ready to make his bow and soak up the San Siro atmosphere.
Roberto Mancini has to completely revamp his defence, as Andrea Ranocchia, Juan Jesus and creative midfielder Mateo Kovacic are all suspended.
Yuto Nagatomo is away on international duty at the Asian Cup, while Daniel Osvaldo has been frozen out after attempting to attack teammate Mauro Icardi for failing to pass him the ball.
This means Nemanja Vidic gets his first start since Mancini replaced Walter Mazzarri in November with Marco Andreolli and Hugo Campagnaro making up the numbers.
Genoa come to San Siro as the favourites thanks to their five-point advantage over more prestigious club Inter.
It’s a satisfying moment for Coach Gasperini, who confessed it was “a mistake” to take the Inter job in 2011, where he was fired after just five games.
The Grifone have slowed down considerably in recent weeks, picking up just one point from the last three rounds.
Diego Perotti and Facundo Roncaglia sit out bans with Giovanni Marchese sidelined.
Ex-Milan striker Alessandro Matri will be eager to make his mark in this stadium where he failed to do so in a Rossoneri jersey.
Nicolas Andre Burdisso also comes face to face with his old team.
Genoa have not won this fixture since March 1994, managing only three draws from the next 11 encounters.
Inter: Handanovic; Campagnaro, Vidic, Andreolli, D’Ambrosio; Medel, Guarin; Palacio, Hernanes, Podolski; Icardi
Inter bench: Carrizo, Berni, Kuzmanovic, Obi; Dodò, Mbaye, Puscas, Krhin, Donkor, M'Vila, Shaqiri
Genoa: Perin; Izzo, Burdisso, De Maio; Edenilson, Rincon, Bertolacci, Antonelli; Iago Falque, Matri, Lestienne
Genoa bench: Lamanna, Prisco, Antonini, Fetfatzidis, Tino Costa, Kucka, Mandragora, Sturaro, Rosi