Inter desperately need a win to stay in touch with the Serie A leaders, but Borja Valero faces an emotional reunion with Fiorentina.
It kicks off at 19.45 GMT, follow the build-up and action from this game and Chievo-Udinese on the LIVEBLOG.
The Nerazzurri were top of the table and unbeaten only a few weeks ago, but slipped seven points off leaders Napoli with one point from three rounds.
Inter desperately need a win to stay in touch with the Serie A leaders, but Borja Valero faces an emotional reunion with Fiorentina.
It kicks off at 19.45 GMT, follow the build-up and action from this game and Chievo-Udinese on the LIVEBLOG.
The Nerazzurri were top of the table and unbeaten only a few weeks ago, but slipped seven points off leaders Napoli with one point from three rounds.
Luciano Spalletti’s men also crashed out of the Coppa Italia, losing to Milan in extra time, so morale is lower than it has been at any stage this season.
Joao Miranda and Danilo D’Ambrosio are still out injured, so Andrea Ranocchia has shaken off a knock to start again in defence.
In a real surprise, Joao Mario is given a very rare start in place of Antonio Candreva.
It’s a big game for Borja Valero, who was so beloved by Fiorentina fans they nicknamed him The Mayor of Florence.
The Spanish midfielder confirmed the affection was mutual by getting a tattoo of the Ponte Vecchio co-ordinates.
It’s also a reunion for Stefano Pioli, who was briefly on the Inter bench last season before his dismissal.
He has done surprisingly well at Fiorentina, given limited resources, and here must do without injured Bruno Gaspar.
Federico Chiesa has been linked with a move to Inter and is back in the starting XI after he was rested against Milan, supporting Giovanni Simeone – the son of ex-Nerazzurri midfielder Diego.
Inter’s last Serie A win in Florence was in February 2014, followed by three consecutive defeats here, including last season’s ridiculous 5-4 thriller.
Their last five meetings, home and away, provided a total 26 goals.
Fiorentina: Sportiello; Laurini, Pezzella, Astori, Biraghi; Benassi, Badelj, Veretout; Chiesa, Simeone, Thereau
Fiorentina bench: Dragowski, Cerofolini, Olivera, Hugo, Sanchez, Milenkovic, Cristoforo, Eysseric, Saponara, Dias, Lo Faso, Babacar
Inter: Handanovic; Cancelo, Skriniar, Ranocchia, Santon; Vecino, Gagliardini; Joao Mario, Borja Valero, Perisic; Icardi
Inter bench: Padelli, Berni, Karamoh, Eder, Dalbert, Nagatomo, Brozovic, Candreva, Lombardoni
Ref: Valeri