Gianluca Lapadula is picked ahead of Carlos Bacca, while Alessio Romagnoli returns as Milan visit Empoli.
It kicks off at the Stadio Castellani at 19.45 GMT, follow the build-up and action on the LIVEBLOG.
The Rossoneri are in joint second place with Roma despite a last-gasp equaliser from Inter in last week’s Derby della Madonnina.
Coach Vincenzo Montella rotates some of his players, resting Bacca, M’Baye Niang and Juraj Kucka.
Gianluca Lapadula is picked ahead of Carlos Bacca, while Alessio Romagnoli returns as Milan visit Empoli.
It kicks off at the Stadio Castellani at 19.45 GMT, follow the build-up and action on the LIVEBLOG.
The Rossoneri are in joint second place with Roma despite a last-gasp equaliser from Inter in last week’s Derby della Madonnina.
Coach Vincenzo Montella rotates some of his players, resting Bacca, M’Baye Niang and Juraj Kucka.
Instead, Lapadula gets a rare start in attack, as his remarkable work rate could be effective against Empoli.
Mati Fernandez and Mario Pasalic step into midfield, moving Jack Bonaventura into the trident attack.
Romagnoli returns from injury, but Gabriel Paletta is rested, giving Gomez another chance to learn on the job in Serie A.
The starting XI this evening has an average age of 23.6 years – the youngest Rossoneri line-up since 1985.
It is also Empoli's 400th match in the Italian top flight.
Empoli have had a dismal campaign, failing to find the net in nine of their last 10 games.
It’s a very special match for Riccardo Saponara, who flopped in a brief spell at San Siro and was sold back to Empoli.
Vincent Laurini, Marco Zambelli and Levan Mchedlidze are on the treatment table.
Last season this fixture ended 2-2 at the Castellani, but Empoli have only beaten Milan once in the last 11 years, their 1-0 win at San Siro in 2007.
Empoli: Skorupski; Veseli, Bellusci, Costa, Pasqual; Krunic, Diousse, Croce; Saponara; Marilungo, Maccarone
Empoli bench: Pugliesi, Pelagotti; Zambelli, Dimarco, Barba, Cosic, Mauri, Maiello, Pereira, Buchel, Tello, Gilardino
Milan: Donnarumma; Abate, Romagnoli, Gomez, De Sciglio; Mati Fernandez, Locatelli, Pasalic; Bonaventura, Lapadula, Suso
Milan bench: Gabriel, Guarnone, Paletta, Zapata, Antonelli, Poli, Sosa, Kucka, Bertolacci, Honda, Luiz Adriano, Niang