Lazio visit Hellas Verona on Monday and there are concerns over the fitness levels of both Ciro Immobile and Felipe Anderson.
It kicks off at the Stadio Bentegodi at 17.30 UK time (16.30 GMT).
Stefan Radu is certainly not making the trip, as he is out for three weeks with a thigh strain.
Sky Sport Italia also warn there are doubts around Immobile and his natural replacement as the False 9, Felipe Anderson.
Immobile made his comeback in the starting XI for the midweek Coppa Italia quarter-final defeat to Juventus, lasting only 45 minutes before he was substituted at half-time.
Felipe Anderson has been his stand-in, moving to a centre-forward role, but now the Brazilian is also struggling with a muscular issue.
Of the two, Immobile is more likely to start, so Pedro could step in for Felipe Anderson, leaving ex-Verona player Mattia Zaccagni on the other flank.
Sergej Milinkovic-Savic and goalkeeper Ivan Provedel were rested in the Coppa Italia, but both return to the starting XI.
Lazio (probable) Provedel; Marusic, Casale, Romagnoli, Hysaj; Cataldi, Milinkovic-Savic, Luis Alberto; Pedro, Immobile, Zaccagni