Juventus could drop Paulo Dybala, Douglas Costa and Joao Cancelo against Lazio, while Lucas Leiva and Senad Lulic return for the visitors.
It kicks off at 17.00 UK time (16.00 GMT), click here for a match preview.
The Bianconeri started their campaign with a hard-fought 3-2 victory away to Chievo and Coach Max Allegri is considering numerous changes.
Juventus could drop Paulo Dybala, Douglas Costa and Joao Cancelo against Lazio, while Lucas Leiva and Senad Lulic return for the visitors.
It kicks off at 17.00 UK time (16.00 GMT), click here for a match preview.
The Bianconeri started their campaign with a hard-fought 3-2 victory away to Chievo and Coach Max Allegri is considering numerous changes.
According to the latest reports from Turin, Cristiano Ronaldo is the only player certain to retain his spot in attack, as the 4-2-3-1 formation is scrapped in favour of a 4-3-3.
This means the likes of Joao Cancelo, Cuadrado, Dybala and Douglas Costa could be left out of the starting XI to make way for Andrea Barzagli, Blaise Matuidi and Mario Mandzukic.
Another option would be to see Douglas Costa re-routed to the right side of a trident attack with Mandzukic as centre-forward and Ronaldo on the left.
Lazio opened the season with a 2-1 defeat to Napoli, having initially taken the lead through Ciro Immobile’s spectacular solo effort.
Simone Inzaghi lost Luiz Felipe to injury in that match, but can now welcome back Lucas Leiva and Senad Lulic from suspension.
Wallace is the favourite to step in to defence, while Martin Caceres and Milan Badelj drop to the bench.
Juventus (probable): Szczesny; Barzagli, Bonucci, Chiellini, Alex Sandro; Khedira, Pjanic, Matuidi; Douglas Costa, Mandzukic, Cristiano Ronaldo
Lazio (probable): Strakosha; Wallace, Acerbi, Radu; Marusic, Parolo, Leiva, Milinkovic-Savic, Lulic; Luis Alberto; Immobile