Lazio have an extremely difficult task on their hands in the Europa League play-off, as Ciro Immobile is out, so Felipe Anderson acts as False 9 against some frankly surprising FC Porto picks.
It kicks off in Portugal at 20.00 GMT, you can follow all the build-up and action as it happens from this game, Barcelona-Napoli and Atalanta-Olympiacos on the LIVEBLOG.
Europa League Liveblog: Barcelona-Napoli, Porto-Lazio, Atalanta-Olympiacos
This new fixture was introduced by UEFA for the teams that finished second in their Europa League groups and third in the Champions League.
Maurizio Sarri’s Lazio have underperformed in Europe so far this season and the task is made even tougher because top scorer Immobile has not made the trip due to a high fever.
Francesco Acerbi and Manuel Lazzari are injured, so Felipe Anderson is the only real alternative as a False 9, flanked by Pedro and Mattia Zaccagni.
At least Luis Alberto and Lucas Leiva can start, as they are suspended for this weekend’s Serie A trip to Udinese anyway.
FC Porto have been very impressive in recent years, causing huge problems for Juventus and Roma on the European stage.
Their coach is former Lazio, Parma and Inter midfielder Sergio Conceicao.
Veteran Pepe is in defence, while Evanilson and Taremi have between them scored 27 competitive goals so far this season, yet they are both on the bench, as Sergio Conceicao made some odd choices.
FC Porto: Diogo Costa; Joao Mario, Mbemba, Pepe, Zaidu; Otavio, Grujic, Matheus Uribe; Fabio Vieira, Toni Martinez, Pepé
Lazio: Strakosha; Marusic, Luiz Felipe, Patric, Radu; Milinkovic-Savic, Lucas Leiva, Luis Alberto; Pedro, Felipe Anderson, Zaccagni