Matthijs de Ligt and Dusan Vlahovic could also miss out on tonight’s game between Juventus and Sassuolo after Juan Cuadrado joined the injury list.
It kicks off at the Mapei Stadium at 19.45 UK time (18.45 GMT).
The Bianconeri are already forced to do without injured Cuadrado, Arthur Melo, Manuel Locatelli, Kaio Jorge, Federico Chiesa and Weston McKennie.
According to the latest reports from Sky Sport Italia, De Ligt is also not fully fit due to a stomach bug, so Giorgio Chiellini has to partner Leonardo Bonucci at centre-back.
Danilo is struggling too with a knock to his foot, but will grit his teeth to start in midfield, where he needs to plug the gaps.
There are suggestions top scorer Vlahovic could be given a very rare rest upfront, with Alvaro Morata partnering Paulo Dybala in a 4-4-2 formation.
Federico Bernardeschi can step in to help the midfield in a variety of roles after scoring in the midweek Coppa Italia semi-final victory over Fiorentina.
La Juve perde i pezzi: anche de Ligt salta il Sassuolo https://t.co/gQUaobTrtB pic.twitter.com/XMclILgdrW
— ilbianconero (@ilbianconerocom) April 25, 2022
Just like Allegri’s last two seasons at Milan when half the team was constantly on the treatment table. People forget that, and now we’re seeing it at Juve.
@Gio Yeah what’s he been feeding De Ligt? Geez, everything is his fault.