Mauro Icardi and Ciro Immobile face off as Inter and Lazio go head-to-head in the Coppa Italia quarter-final.
It kicks off at San Siro at 20.00 GMT and the winner goes on to play Milan in the two-legged semi-final.
The other semi will be between giant-killers Fiorentina and Atalanta, so this could be the most open Coppa in many years.
Inter leave Ivan Perisic on the bench after rejecting an offer from Arsenal, as with the transfer deadline now passed, he can begin focusing on the task at hand.
Mauro Icardi and Ciro Immobile face off as Inter and Lazio go head-to-head in the Coppa Italia quarter-final.
It kicks off at San Siro at 20.00 GMT and the winner goes on to play Milan in the two-legged semi-final.
The other semi will be between giant-killers Fiorentina and Atalanta, so this could be the most open Coppa in many years.
Inter leave Ivan Perisic on the bench after rejecting an offer from Arsenal, as with the transfer deadline now passed, he can begin focusing on the task at hand.
Matteo Politano is suspended this weekend in Serie A, so he is given a starting spot with Icardi and Antonio Candreva.
Keita Balde Diao, Sime Vrsaljko and former Lazio defender Stefan de Vrij all miss out through injury.
There was a late change, as Borja Valero pulled out during the warm-up, replaced by Joao Mario.
Lazio midfielder Danilo Cataldi sits out a ban, with Luiz Felipe and Patric side-lined, but Francesco Acerbi returns after his suspension against Juventus.
Adam Marusic is also back from the naughty step, with Joaquin Correa, Lucas Leiva, Luis Alberto and Sergej Milinkovic-Savic supporting Immobile.
These two clubs are historically twinned, but the rapport has been dampened lately by a series of showdowns for fourth place in Serie A.
It culminated in last season’s comeback, as Inter conquered the Olimpico to take the final Champions League spot.
Lazio have not beaten Inter since a 2-1 Coppa Italia quarter-final at San Siro precisely two years ago: January 31, 2017.
That was followed by one draw from four competitive encounters, home and away.
Inter: Handanovic; D'Ambrosio, Skriniar, Miranda, Asamoah; Gagliardini, Brozovic, Joao Mario; Politano, Icardi, Candreva
Lazio: Strakosha; Wallace, Acerbi, Radu; Marusic, Milinkovic-Savic, Leiva, Luis Alberto, Lulic; Correa; Immobile
Ref: Abisso