Federico Chiesa and Alvaro Morata are expected to start for Juventus, while Brahim Diaz pushes both Rafael Leao and Ante Rebic to the Milan bench.
It kicks off on Sunday at 19.45 UK time (18.45 GMT), click here for a match preview.
This is a huge fixture for both teams, who are locked together in joint second place with Atalanta.
According to Sky Sport Italia, Chiesa has fully recovered after missing the last three games and could even be in the starting XI.
Federico Chiesa and Alvaro Morata are expected to start for Juventus, while Brahim Diaz pushes both Rafael Leao and Ante Rebic to the Milan bench.
It kicks off on Sunday at 19.45 UK time (18.45 GMT), click here for a match preview.
This is a huge fixture for both teams, who are locked together in joint second place with Atalanta.
According to Sky Sport Italia, Chiesa has fully recovered after missing the last three games and could even be in the starting XI.
Morata is the favourite to partner Cristiano Ronaldo rather than Paulo Dybala, while Giorgio Chiellini is a contender to start with Leonardo Bonucci instead of Matthijs de Ligt.
As for Milan, the big decision is who will support Zlatan Ibrahimovic, along with Hakan Calhanoglu and Alexis Saelemaekers.
While the debate had been between Leao and Rebic, there has been a sudden switch and reports Brahim Diaz will be chosen ahead of both of them.
Probable line-ups
Juventus: Szczesny; Danilo, Bonucci, Chiellini, Alex Sandro; Cuadrado, Bentancur, Rabiot, Chiesa; Morata, Ronaldo
Milan: G Donnarumma; Calabria, Kjaer, Tomori, Theo Hernandez; Bennacer, Kessie; Saelemaekers, Calhanoglu, Brahim Diaz; Ibrahimovic