Inter look to Lautaro Martinez and Edin Dzeko to end their goal drought, but are still missing Hakan Calhanoglu in the Champions League quarter-final with Benfica, who have a reshuffled defence and Joao Mario eager to prove a point.
It kicks off at the Estadio da Luz at 20.00 UK time (19.00 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
The away goals rule no longer applies, so if the teams are level on aggregate after the second leg on April 19, they’ll go to extra time and maybe even penalties.
The Nerazzurri already knocked FC Porto out in the Round of 16, so hope the Portuguese soil brings them luck once more, especially after a dismal run of domestic form saw them manage just one win, two draws and four defeats between Serie A, the Champions League and Coppa Italia.
In that streak of eight games, Inter scored only five goals and two of them were penalties.
Edin Dzeko gets the nod with Lautaro Martinez, supported by Marcelo Brozovic and Henrikh Mkhitaryan, as Hakan Calhanoglu and Milan Skriniar are still out injured.
Benfica have to completely reshuffle their defence, as Nicolas Otamendi is suspended, with Alexander Bah, Gonçalo Guedes and Julian Draxler injured.
It is a very special game for Joao Mario, who Inter purchased from Sporting CP for €45m in 2016 and proved to be a costly flop, sent out on multiple loan moves until a free transfer to Benfica in 2021.
He has since positively flourished and this season contributed 23 goals and 12 assists in 42 competitive matches, including six strikes in the Champions League.
Gonçalo Ramos is Benfica’s top scorer on 25 goals, supported by Rafa Silva.
Benfica topped their Champions League group ahead of PSG and Juventus, crushing Club Brugge 7-1 on aggregate in the Round of 16, and are still unbeaten in the competition this season.
Their only stalemates were 1-1 home and away with PSG in October.
They remain runaway leaders of the Liga, but their run of 10 victories in a row was ended on Friday by a 2-1 home defeat to rivals FC Porto.
Benfica: Vlachodimos; Gilberto, Morato, Antonio Silva, Grimaldo; Florentino, Chiquinho; Rafa Silva, Joao Mario, Aursnes; Gonçalo Ramos
Benfica bench: Samuel Soares, Andre Gomes, Verissimo, Neres, Goncalo Guedes, Tengstedt, Schjelderup, Musa, Rafael Rodrigues, Joao Tome, N’Dour, Joao Neves
Inter: Onana; Darmian, Acerbi, Bastoni; Dumfries, Barella, Brozovic, Mkhitaryan, Dimarco; Lautaro Martinez, Dzeko
Inter bench: Handanovic, Cordaz, Gagliardini, De Vrij, Gosens, Correa, Bellanova, Asllani, D’Ambrosio, Carboni, Zanotti, Lukaku
Ref: Oliver (ENG)
Player statistic
| António Silva |  |
22' |
| 50' | |
Marcelo Brozovic | ||
| 51' |  |
Nicolò Barella (Assist: Alessandro Bastoni) | ||
| 81' |  |
Romelu Lukaku | ||
| 83' | |
Edin Dzeko |
Match statistic
