Milan bring back Mike Maignan and Theo Hernandez to join Rafael Leao, Christian Pulisic and Olivier Giroud against PSG stars Gianluigi Donnarumma and Kylian Mbappé.
It kicks off at the Parc des Princes at 20.00 UK time (19.00 GMT).
This was always going to be the biggest clash of the group, but it has also turned into a head-to-head for survival, because Newcastle United are surprisingly top on four points, followed by PSG with three, Milan two and Borussia Dortmund one.
The Rossoneri have not even scored yet, despite numerous opportunities, and hope to change that trend with their classic front three.
Ruben Loftus-Cheek, Noah Okafor, Samuel Chukwueze and Ismael Bennacer are out injured, but Rade Krunic and Pierre Kalulu return to the starting XI.
Maignan and Theo Hernandez were suspended for Sunday’s 1-0 Serie A defeat to Juventus.
Paris Saint-Germain are missing Marco Asensio, Presnel Kimpembe and Nuno Mendes, but it is the first time Gigio Donnarumma has faced his former club.
There are other familiar faces, including ex-Inter players Milan Skriniar and Achraf Hakimi, former Napoli midfielder Fabian Ruiz, Italy Under-21 international Cher Ndour, while Marquinhos and coach Luis Enrique spent time at Roma.
Lucas Hernandez is up against his brother Theo.
Randal Kolo-Muani gets the nod ahead of Goncalo Ramos to start with Mbappé.
Curiously, the only Italian on the pitch is playing for Paris Saint-Germain.
PSG: Donnarumma; Hakimi, Marquinhos, Skriniar, Lucas Hernandez; Zaire-Emery, Ugarte, Vitinha; Dembélé, Kolo-Muani, Mbappé
PSG bench: Letellier, Tenas; Mukiele; Danilo, Fabián Ruiz, Lee, Soler; Barcola, Ramos
Milan: Maignan; Kalulu, Thiaw, Tomori, Theo Hernandez; Musah, Krunic, Reijnders; Leao, Giroud, Pulisic
Milan bench: Mirante, Nava; Bartesaghi, Calabria, Florenzi, Kjær; Adli, Pobega; Jović, Traorè
Ref: Vincic (SVN)
Player statistic
4' | Malick Thiaw | |||
7' | Rade Krunic | |||
Achraf Hakimi | 16' | |||
Kylian Mbappé (Assist: Warren Zaïre-Emery) |
32' | |||
Ousmane Dembélé | 44' |
Randal Kolo Muani | 53' | |||
61' | Fikayo Tomori | |||
62' | Pierre Kalulu | |||
Kang-In Lee (Assist: Warren Zaïre-Emery) |
89' |