Sampdoria are not yet out of the relegation woods and visit a Bologna side without a win in five rounds.
It kicks off at the Stadio Dall’Ara at 19.45 UK time (18.45 GMT).
The campaign has not gone to plan for either club, both on and off the field, so far this season.
Bologna coach Sinisa Mihajlovic returned to hospital for treatment after his leukaemia returned and will be watching this game from his room after a creditable 0-0 draw with leaders Milan.
Samp sacked Roberto D’Aversa and brought in Marco Giampaolo, but have lost four of their last five games and are still hovering above the relegation zone.
Lorenzo De Silvestri is out injured and Gary Medel returns after a clash of heads with Zlatan Ibrahimovic.
Sebastian Giovinco, Manolo Gabbiadini and Mikkel Damsgaard are still on the Blucerchiati treatment table.
Bologna: Skorupski; Soumaoro, Medel, Theate; Hickey, Aebischer, Schouten, Svanberg, Dijks; Barrow, Arnautovic
Sampdoria: Audero; Bereszynski, Ferrari, Colley, Murru; Candreva, Rincon, Thorsby; Sensi; Sabiri, Caputo