Juventus must beat Malmo and hope Chelsea slip up against Zenit in order to snatch top spot, giving Arthur a rare start in midfield.
It kicks off at the Allianz Juventus Stadium in Turin at 17.45 GMT.
Champions League Liveblog: Juventus-Malmo, Atalanta-Villarreal
The Bianconeri have already qualified for the Round of 16, but can still finish top of this group if they win and Chelsea fail to pick up all three points in Russia.
Max Allegri has limited squad rotation options, because Federico Chiesa, Dejan Kulusevski, Danilo, Weston McKennie and Aaron Ramsey are all injured.
Leonardo Bonucci therefore returns in defence after back-to-back games on the bench, with Daniele Rugani and youth team player Koni De Winter.
Arthur gets his chance in midfield, with Paulo Dybala and Moise Kean upfront, despite the Italy international having a slight ankle issue.
Malmo look to former Sampdoria defender Niklas Moisander and their coach is ex-Milan striker Jon Dahl Tomasson.
Felix Beijmo and Oscar Lewicki are injured, but Anders Christiansen starts.
It has been snowing all day in Turin, so the atmosphere should be fairly familiar for the Swedish side.
Juventus: Perin; De Winter, Bonucci, Rugani; Bernardeschi, Bentancur, Arthur, Rabiot, Alex Sandro; Dybala, Kean
Juventus bench: Szczesny, Pinsoglio, De Sciglio, Chiellini, De Ligt, Morata, Cuadrado, Locatelli, Da Graca, Miretti
Malmo: Diawara; Moisander, Ahmedhodzic, L Nielsen, M Olsson; Berget, Christiansen, Innocent, Rakip; Birmancevic, Colak
Malmo bench: Ellborg, Dahlin, Larsson, Pena, Abubakari, Gwargis, Nalic, Brorsson, Nanasi
Ref: Peljto (BIH)