Fikayo Tomori has reportedly not suffered a relapse of his hip injury, but is not even on the Milan bench against Tottenham Hotspur as a precaution.
The Champions League Round of 16 tie kicks off at 20.00 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The second leg will be in London on March 8.
Tomori had been expected to make his comeback to the starting XI this evening after sustaining a hip injury during the 4-0 defeat to Lazio on January 24.
Instead, he is not even on the bench, but Sky Sport Italia assure there has been no relapse.
The England international defender had a fitness test and felt some pain when kicking the ball.
With that in mind, and the importance of this match, it was decided not to risk even having Tomori on the bench.
He is instead replaced by Simon Kjaer, while Malick Thiaw completes the experimental back three with Pierre Kalulu.