Emil Audero made several big saves to rescue a point for Sampdoria, as Sassuolo failed to make their chances count.
The Neroverdi were still without captain Domenico Berardi amid a transfer tug-of-war, plus injured Pedro Obiang, Matheus Henrique and Filippo Romagna following their 3-2 win away to Verona. Samp lost 1-0 to Milan and Manolo Gabbiadini sprained his ankle in the opening weekend.
Filip Djuricic and Francesco Caputo tested Emil Audero early, but the visitors improved as the game wore on, several Antonio Candreva crosses causing panic.
Maxime Lopez drilled just wide, but Ciccio Caputo really should’ve scored straight after the restart when pouncing on an Omar Colley error, only to over-hit the lob.
Emil Audero outdid himself on the hour mark with a stunning flying save to fingertip the Jeremie Boga curler out of the far top corner.
It was all Sassuolo in the second half, Rogerio skimming the bar with a scorcher and Audero using his legs to deny Filip Djuricic from the tightest of angles.
Sassuolo 0-0 Sampdoria