Ante Rebic will replace the injured Olivier Giroud for Milan against Lecce in a must-win game for both teams at San Siro.
It kicks off at 17:00 GMT+1.
The Rossoneri are without the France striker, so Rebic is expected to start in attack. Rafael Leao, Ismael Bennacer and Brahim Diaz – favourite over Alexis Saelemaekers – will play behind the Croatian forward.
Captain Davide Calabria is suspended and will be replaced by Pierre Kalulu.
Milan have qualified for the Champions League semi-finals but collected six points in the last six games and need a win to keep their top-four finish hopes alive.
Lecce have travelled to Milan without the injured Lorenzo Colombo and Marin Pongracic. The Rossoblu have lost the last three away games and ended a six-match losing streak last week with a 1-1 draw against strugglers Sampdoria.
The Giallorossi are also the team with the fewest clean sheets in Serie A this season, only three in 30 matches.
Milan-Lecce: probable line-ups
Milan (4-2-3-1): Maignan; Kalulu, Thiaw, Tomori, Theo; Krunic, Tonali; Diaz, Bennacer, Leao; Rebic.
Lecce (4-3-3): Falcone; Gendrey, Baschirotto, Umtiti, Pezzella; Oudin, Hjlumand, Blin; Strefezza, Ceesay, Di Francesco.