Torino try to get back on track with Nikola Vlasic leading the way against a decimated Sassuolo side who debuts an 18-year-old.
It kicks off at the Stadio Olimpico Grande Torino at 19.45 UK time (18.45 GMT).
The Granata are flying high this season, despite losing two of the last three games against Atalanta and Inter.
Samuele Ricci, Aleksey Miranchuk and Etrit Berisha are on the treatment table, so Nikola Vlasic and Demba Seck support Nemanja Radonjic.
Sassuolo have not had the start to the season they were looking for, managing only one victory and losing 3-1 at home to Udinese last week.
That game saw them reduced to 10 men and Ruan Tressoldi therefore sits out a ban, with Domenico Berardi, Hamed Junior Traore, Mert Muldur and Gregoire Defrel injured.
Armand Lauriente has made a good impression since his summer move and starts with Andrea Pinamonti.
The big surprise is that Luca D’Andrea is thrown in from the start for his Serie A debut, just 11 days after he turned 18.
Torino: Milinkovic-Savic; Djidji, Buongiorno, Schuurs; Lazaro, Lukic, Linetty, Singo; Vlasic, Seck; Radonjic
Sassuolo: Consigli; Toljan, Ayhan, Ferrari, Rogerio; Frattesi, Maxime Lopez, Harroui; D’Andrea, Pinamonti, Laurienté