Napoli rely on Victor Osimhen, Lorenzo Insigne and Kalidou Koulibaly against Inter’s Edin Dzeko, Lautaro Martinez and Denzel Dumfries in this Scudetto showdown.
It kicks off at the Stadio Diego Armando Maradona at 17.00 GMT.
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There is only one point separating these teams going into the fixture, although Inter do have a game in hand.
Napoli have Koulibaly back for the first time in 2022 after he won the Africa Cup of Nations with Senegal, while Osimhen scored his first goal last week since the devastating facial fractures he sustained in a clash of heads with Inter defender Milan Skriniar in October.
Insigne completes the supporting trio with Piotr Zielinski and ex-Inter player Matteo Politano, as Hirving Lozano and Axel Tuanzebe are injured.
Inter have Alessandro Bastoni suspended after the fiery ending to the Milan Derby, though they are appealing the two-match ban.
Coach Simone Inzaghi is also barred from the touchline for insulting the referee.
Joaquin Correa, Robin Gosens and Matias Vecino didn’t make the trip, but Felipe Caicedo is on the bench for the first time since joining from Genoa in January.
Edin Dzeko and Lautaro Martinez lead the way with Hakan Calhanoglu, as Alexis Sanchez is on the sidelines, while Federico Dimarco is chosen to complete the defence.
Napoli: Ospina; Di Lorenzo, Rrahmani, Koulibaly, Mario Rui; Lobotka, Fabian Ruiz; Politano, Zielinski, Insigne; Osimhen
Inter: Handanovic; Skriniar, De Vrij, Dimarco; Dumfries, Barella, Brozovic, Calhanoglu, Perisic; Dzeko, Lautaro Martinez